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Over the last decade, numerous studies have been published by our collaborators which demonstrate the correlation in results between RapidFire-MS and LC-MS.

These charts feature RapidFire/MS and LC/MS comparisons for analyses of CYP inhibition (see below), microsomal stability, PAMPA and PPB assays. Click here for more charts and details on these studies.

Please contact us if you have a specific compound or reaction you would like to analyze using RapidFire technology.

cyp inhibition correlation

Medicinal Chemistry – The Online Scientific Community – News: Agilent Technologies and Ameritox Form Collaboration.

If you’re at MSACL this week …. well, we hope you are enjoying an inspiring conference full of great talks and interesting techniques in sunny San Diego.

While there, please make sure you make it to our podium talk to learn how to shorten time to results using our ultrafast online SPE/MS/MS system in forensic tox applications. Here are the details:

WHAT:  Oral presentation, “Rapid Analysis of Drugs of Abuse in Urine for Forensic Toxicology Using Ultra-Fast Online SPE/MS/MS”

WHEN:  Monday, February 11, 3:30pm

WHERE:  Harbor Ballroom 1,  Toxicology I

Abstract
The need for greater analytical capacity and throughput for forensic toxicology applications has placed demands on traditional analytical technologies. We evaluated the ability of an ultra-fast SPE/MS/MS system to analyze drugs of abuse analytes in urine (cannabinoids, benzodiazepines, amphetamines, etc.) with much faster sample cycle times (240 samples per hour).

RapidFire End User Ameritox Corporation issued this press release today about its clinical research collaboration with Agilent Technologies in the field of medication monitoring.

[Note: The Agilent RapidFire/MS system is for research use only and is not for use in diagnostic procedures.]

Sign up now! Agilent will present the findings from a comparison study using SPE/MS (unlabeled) and fluorescence spectroscopy (labeled) for fragment-based screening. The results are compelling. 

Why is this important?  Because although fragment-based screening via HTS allows more comprehensive covereage of chemical space, the typical low potency of fragments, in most cases, leads to the use of physical methods that detect binding.  The few existing functional biochemical assays use optical methods, such as fluorescence spectroscopy, which can be subject to confounding factors due to the high concentrations of compound needed to detect activity.

The work was done by our PhDs in Agilent Discovery Services lab in Wakefield, MA. Data will be presented showing the differences in kinetic parameters, hit rates, and hit sets on a functional screen of ß-amyloid secretase (BACE-1)using both a labeled and an unlabeled.This webinar will be broadcast live (and recorded) two times on Thursday, February 7th, to accomodate a global audience.

All who register will receive a link to view the recording after the broadcast.

Registration links:

Europe
Date: Thursday, February 7, 2013
Time: 10:00am (EST)/ 3:00pm (GMT)
Register here

North America
Date: Thursday, February 7, 2013
Time: 1:30pm (EST) / 10:30am (PST)
Register here

Driving efficiencies and throughput in ADME/PK studies


Tuesday, February 5, 2013
8:00 AM – 9:15 AM PST

REGISTER

In this webinar you will learn about instrumentation that can drive efficiencies in your laboratory through automating manual tasks, facilitating unattended instrument operation, and improving throughput of your ADME/PK assays.

Talk 1 (Vaughn Miller): Increasing Efficiency of ADME Assays Using the High-throughput RapidFire System
Talk 2 (Louis Murray): Automation and liquid handling solutions for ADME/PK studies
Talk 3 (Na Pi): An Automated Online Card Extraction LC/MS System for Dried Blood Spots Analysis

Webinar Participants Will Learn:

• How to perform a variety of in vitro ADME assays with unprecedented throughputs of greater than 350 samples per hour and generate a seven point IC50 curve in under 45 seconds, without compromising data quality, using existing assay methods and workflows.
• How to maximize efficiencies of your ADME/DMPK laboratories by introducing automation to your liquid handling and sample preparation workflows, and by facilitating unattended operation of analytical instrumentation.
• How to utilize a fully automated card extraction LC/MS system to simplify your quantitative analysis of target drugs and metabolites in Dried Blood Spots (DBS) or other dried matrix spots.

Who Should Attend?

• Researchers who conduct in vitro or in vivo ADME/PK assays
• Lab managers and scientists focused on ADME/PK research in Biotech, Pharmaceutical companies and CRO’s
• Project leaders, medicinal chemists and biologists interested in obtaining critical ADME/PK data to drive their drug discovery programs forward
• Academicians and students interested in new ADME/PK automation and analytical technologies

Speakers:

Vaughn Miller, Ph.D.
Applications Manager, Rapidfire High-Throughput MS systems
Agilent Technologies Inc.

Louis Murray
Applications Engineer, Automation
Agilent Technologies Inc.

Na Pi Parra, Ph.D.
Product Manager, LC/MS Triple Quadrupole Products
Agilent Technologies Inc.

msaclHere’s a preview of talks and posters featuring RapidFire technology at February’s MSACL meeting. When visiting the exhibit hall, please look for Agilent in booth #24.

Podium presentation (Monday 3:30pm, Toxicology Track)

“Rapid Analysis of Drugs of Abuse in Urine for Forensic Toxicology Using Ultra-Fast Online SPE/MS/MS”

Posters

  1. Ultrafast Analysis of Panels of Synthetic Drugs of Abuse in Urine Using Online SPE/MS/MS
  2. Ultrafast Analysis of an Immunosuppressant Drug Panel in Whole Blood Using a High-Throughput SPE/MS/MS System
  3. Ultrafast Simultaneous Analysis of 6 Antiepileptic Drugs in Human Serum Using Online SPE/MS/MS
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